HBx M130K and V131I (T-A) mutations in HBV genotype F during a follow-up study in chronic carriers.

ABSTRACT:

Background

Around 400 million people worldwide are chronically infected with Hepatitis B virus (HBV). An estimated 10% of these chronic patients develop progressive liver damage including cirrhosis and Hepatocellular Carcinoma (HCC). The HBx gene encodes a protein of 154 amino acids which is a transactivator and has been associated with HBV pathogenesis. A change in the amino acid sequences at positions 130 and 131 in the HBV-X protein (M130K and V131I) produced by T-A point mutations at the nucleic acids level has been associated with severe liver damage and HCC in patients from China and Africa. Further, such changes have been proposed as a prognostic marker for progressive liver damage and HCC. The purpose of this study was to determine if T-A mutations are present in HBV chroni

SUBMITTER: Leon B 

PROVIDER: S-EPMC1199628 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature