Unraveling the mesoscale resting-state functional connectivity of ocular dominance columns in humans using high-resolution functional MRI.

ABSTRACT: Despite their importance for visual perception, functional connectivity between ocular dominance columns (ODCs) in the human primary visual cortex (V1) remains largely unknown. Using high-resolution functional MRI (fMRI), we localized ODCs and assessed their resting-state functional connectivity (rs-FC) in 12 human adults. Consistent with anatomical studies in animals, we found stronger rs-FC in the middle compared to deep and superficial cortical depths and selectively stronger rs-FC between ODCs with alike compared to unalike ocular polarity. Beyond what was known from animal models, and consistent with human perceptual biases, intra- and interhemispheric rs-FC was stronger in peripheral (compared to central) and in dorsal (compared to ventral) V1 subregions. Lastly, rs-FC patterns corre

SUBMITTER: Schmidt ME 

PROVIDER: S-EPMC11996315 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature