Epidemiology of Nontyphoidal <i>Salmonella</i> Infections in Korean Children and Genetic Factors Associated with Extra-intestinal Invasion: A Whole-genome Sequencing Analysis.

ABSTRACT:

Background

Understanding the virulence and pathogenicity of invasive nontyphoidal Salmonella (iNTS) in children may support timely treatment and enable closer monitoring of chronic infections. iNTS epidemiology in Asia remains inadequately described. We analyzed the genetic diversity and virulence genes associated with extra-intestinal invasion in Korean children.

Methods

Salmonella isolates from children <18 yrs of age diagnosed with moderate-to-severe salmonellosis between January 2019 and December 2021 were subjected to antibiotic susceptibility testing and whole-genome sequencing.

Results

In total, 58 cases were included. We identified 20 serotypes, the most prevalent being Salmonella Enteritidis (N=21), followed by Infantis (N=6), I 4,[5],12:i:- (N=

SUBMITTER: Kang HM 

PROVIDER: S-EPMC11996685 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature