Clinical Implications of Circulating Tumor DNA in Multiple Myeloma and Its Precursor Diseases.

ABSTRACT:

Background

Genetic alterations play a pivotal role in multiple myeloma (MM) development and therapeutic resistance. Traditionally, the genetic profiling of MM requires invasive bone marrow (BM) procedures; however, these procedures are associated with patient discomfort and cannot fully capture the spatial and temporal heterogeneity of the disease. Therefore, we investigated the clinical implications of liquid biopsy using targeted deep sequencing.

Methods

We analyzed the genetic profiles of circulating tumor DNA (ctDNA) by targeted deep sequencing from 102 patients, including those with monoclonal gammopathy of undetermined significance (MGUS, N=7), smoldering MM (N=6), and symptomatic MM (N=89).

Results

The number of ctDNA mutations increased with disease progressio

SUBMITTER: Park SS 

PROVIDER: S-EPMC11996693 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature