Collagen turnover during cervical remodeling involves both intracellular and extracellular collagen degradation pathways†.

ABSTRACT: Reproductive success requires accurately timed remodeling of the cervix to orchestrate the maintenance of pregnancy, the process of labor, and birth. Prior work in mice established that a combination of continuous turnover of fibrillar collagen and reduced formation of collagen cross-links allows for the gradual increase in tissue compliance and delivery of the fetus during labor. However, the mechanism for continuous collagen degradation to ensure turnover during cervical remodeling is still unknown. This study demonstrates the functional role of extracellular and intracellular collagen degradative pathways in two different settings of cervical remodeling: physiological term remodeling and inflammation-mediated premature remodeling. Extracellular collagen degradation is achieved by the ac

SUBMITTER: Colon-Caraballo M 

PROVIDER: S-EPMC11996760 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature