Efficacy and safety of topical minocycline preparations for papulopustular rosacea: a systematic review and meta-analysis.

ABSTRACT:

Background

Rosacea is a chronic inflammatory skin condition. Papulopustular rosacea (PPR), one of the subtypes of rosacea, presents with papules and pustules (Pelle, 2008). Topical minocycline allow the delivery of high concentrations of the medication to the skin while decreasing systemic exposure thereby evading side effects (Jones et al., 2021, Webster et al., 2020). This study aims to review the literature to delineate the efficacy and safety of topical preparations of minocycline in the treatment of moderate to severe papulopustular rosacea.

Methods

This systematic review included randomized clinical trials (RCT) only that compared the efficacy and safety of 1.5% minocycline foam and 1%, 3% minocycline gel versus placebo in patients with moderate to severe papulopustula

SUBMITTER: Alamri A 

PROVIDER: S-EPMC11996761 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature