Comparative analysis of inflammatory markers as predictive markers for postoperative delirium in cardiac surgery patients: an observational study.

ABSTRACT:

Background

Postoperative delirium (POD) is a common complication following cardiac surgery that significantly affects patient outcomes. Among inflammatory markers, the monocyte-to-lymphocyte ratio (MLR) has shown potential in predicting POD. However, studies on the relationship between neutrophil-to-lymphocyte ratio (NLR) or platelet-to-lymphocyte ratio (PLR) and POD are still lacking. Moreover, a direct comparison of the predictive capabilities of these three inflammatory markers (NLR, MLR, and PLR) for POD remains unexplored.

Methods

This observational study utilized the MIMIC database. We included 2,095 patients who underwent cardiac surgery. Multivariable logistic regression analysis, restricted cubic spline (RCS) analysis, and receiver operating characteristic (ROC) cur

SUBMITTER: Shan L 

PROVIDER: S-EPMC11996787 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature