Cyclic dipeptides from endophytic bacterium <i>Bacillus velezensis</i> as potential flavor precursors.

ABSTRACT: Cyclic dipeptides represent a class of intriguing molecules with a wide range of biological activities, but their potential application as flavor precursors has not been previously reported. In this study, a flavor-producing bacterium Bacillus velezensis was screened out from 35 isolated endophytic bacteria. Gas chromatography-mass spectrometry (GC-MS) analysis suggested that the fermentation broth of B. velezensis contained flavor compounds and high amount of cyclic dipeptide flavor precursors. Three cyclic dipeptide flavor precursors, namely cyclo (L-prolyl-L-valine) (1), cyclo (L-prolyl-L-isoleucine) (2), and cyclo (L-prolyl-L-leucine) (3), were further isolated from the fermentation broth extraction through Sephadex LH-20 column chromatography and sem

SUBMITTER: Li T 

PROVIDER: S-EPMC11996796 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature