Virus-associated inflammation imprints an inflammatory profile on monocyte-derived macrophages in the human liver.

ABSTRACT: Chronic liver injury triggers the activation and recruitment of immune cells, causing antigen-independent tissue damage and liver disease progression. Tissue inflammation can reshape macrophage composition through monocyte replacement. Replacement of tissue macrophages with monocytes differentiating in an inflammatory environment can potentially imprint a phenotype that switches the liver from an immune-tolerant organ to one predisposed to tissue damage. We longitudinally sampled the liver of patients with chronic hepatitis B who had active liver inflammation and were starting antiviral therapy. Antiviral therapy suppressed viral replication and liver inflammation, which coincided with decreased myeloid activation markers. Single-cell RNA-Seq mapped peripheral inflammatory markers to a mon

SUBMITTER: Sanchez Vasquez JD 

PROVIDER: S-EPMC11996867 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature