Two chemotherapeutic agents expand stem-like CD62L⁺CD8⁺ T cells in antitumor immune responses.

ABSTRACT:

Introduction

Recent findings reveal that the precursors of exhausted CD8⁺ T (CD8⁺ Tpex) cells possess stem-like signatures in tumor immunity, which originate from tumor draining lymph node (TdLN)-derived tumor-specific memory (CD8⁺ T_TSM) cells. Both of these T subsets can be collectively referred to as stem-like CD8⁺ T cells, which demonstrate robust self-renewal ability and can proliferate and differentiate into transitory effector-like exhausted T cells (Tex^int). There are reports that chemotherapeutic drugs can promote the antitumor immune responses of patients by increasing the number of CD8⁺ T cells; however, whether chemotherapeutic drugs increase these two stem-like CD8⁺ T cells remain fu

SUBMITTER: Ruan X 

PROVIDER: S-EPMC11996895 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature