Progression independent of relapse activity and relapse-associated worsening in seronegative NMOSD: an international cohort study.

ABSTRACT:

Background

Previous studies have indicated that progression independent of relapse activity (PIRA) is uncommon in patients with aquaporin- 4 antibody-positive (AQP4-IgG) neuromyelitis optica spectrum disorder (NMOSD). However, the patterns of disability accumulation in seronegative NMOSD are unknown. This study aimed to evaluate the prevalence of PIRA and relapse-associated worsening (RAW) in seronegative NMOSD.

Methods

We conducted a retrospective, multicentre cohort study of seronegative NMOSD patients from the MSBase registry. Inclusion criteria required at least three recorded expanded disability status scale (EDSS) scores: baseline, progression, and 6 months confirmed disability progression (CDP). For those with 6-month CDP, the presence or absence of relapse between ba

SUBMITTER: Siriratnam P 

PROVIDER: S-EPMC11996963 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature