Mesobuthus eupeus venom modulates colorectal carcinoma signaling pathways and induces apoptosis.

ABSTRACT: Colorectal cancer (CRC) is a significant global health concern, often challenging to treat effectively with conventional methods and burdened by adverse effects. Scorpion venoms offer a unique avenue for exploration, given their ability to disrupt the cell cycle, inhibit growth, and trigger apoptosis. This study delves into the impact of Mesobuthus eupeus (M. eupeus) scorpion venom on the proliferation and progression of colorectal cancer at the molecular level. The total protein concentration in the venom (607.5 µg/mL) also emphasized the rich composition and potential for therapeutic applications. The study reveals that M. eupeus venom effectively reduced the proliferation of DLD-1 and HT-29 colorectal cancer cells in a dose-dependent manner with IC₅₀ values of 4.32 and 7.61 µ

SUBMITTER: Canak HN 

PROVIDER: S-EPMC11996983 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature