Experimental autoimmune encephalomyelitis pathogenesis alters along animal age: impact of S100B expression.

ABSTRACT: Multiple Sclerosis (MS) is the leading inflammatory and non-traumatic cause of disability in young adults, with late-onset MS emerging in middle-aged patients often resulting in poorer treatment responses and worse prognoses. The calcium-binding protein S100B is elevated in MS patients, and its targeting has shown promise in reducing disease severity in experimental autoimmune encephalomyelitis (EAE) models. However, most studies on MS pathology have focused on young animal models, leaving a gap in understanding the effects of age and S100B ablation on disease progression throughout the lifespan. This study aimed to characterize EAE in mice of different ages, examining demyelination, inflammation, and immune responses to determine whether S100B ablation could mitigate MS pathogenesis acros

SUBMITTER: Ribeiro AR 

PROVIDER: S-EPMC11997003 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature