β-adrenergic receptor inhibits heart regeneration by downregulating Yap m6A modification.

ABSTRACT: Newborn mammals transiently maintain the heart regenerative capacity. β-adrenergic receptor (β-AR) is the most critical receptor in regulating cardiomyocyte behavior. However, the role and mechanism of β-AR, especially the subtypes of β-AR, in heart regeneration remain unclear. Here, we reveal that β-AR inhibits heart regeneration by downregulating Yap m6A modification. The β-AR expression is associated with heart regenerative capacity. After apical resection, β-AR (including β₁-AR and β₂-AR) inhibits heart regeneration. β₂-AR exerts a more potent inhibitory effect compared with β₁-AR. Mechanistically, both β₁-AR and β₂-AR downregulate Yap m6A modification and then YAP expression differentially by reducing METTL14 and IGF2BP

SUBMITTER: Guan K 

PROVIDER: S-EPMC11997195 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature