Oncogene-induced senescence mitochondrial metabolism and bioenergetics drive the secretory phenotype: further characterization and comparison with other senescence-inducing stimuli.

ABSTRACT: Cellular senescence is characterized by proliferation arrest and a senescence-associated secretory phenotype (SASP), that plays a role in aging and the progression of various age-related diseases. Although various metabolic alterations have been reported, no consensus exists regarding mitochondrial bioenergetics. Here we compared mitochondrial metabolism of human fibroblasts after inducing senescence with different stimuli: the oxidant hydrogen peroxide (H₂O₂), the genotoxic doxorubicin, serial passage, or expression of the H-RAS^G12V oncogene (RAS). In senescence induced by H₂O₂, doxorubicin or serial passage a decrease in respiratory control ratio (RCR) and coupling efficiency was noted, in relation to control cells. On the contrary,

SUBMITTER: Marmisolle I 

PROVIDER: S-EPMC11997345 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature