Lumbrokinase-containing gelatin nanofibers with multiple bioactivities for effective skin wound healing.

ABSTRACT: Wound healing is a highly complex and intricate biological process involving cellular and molecular events. Given that lumbrokinase is a fibrinolytic enzyme derived from earthworms and exhibits notable anti-inflammatory, anti-fibrotic, and pro-angiogenic functions, this study aims to investigate the development of bioactive gelatin nanofibers containing lumbrokinase (GLK) fabricated through electrospinning as a novel nanomedicine strategy for enhancing wound healing. Our results showed that reducing electrospinning time can increase cross-linking degree and decrease degradation rate to maintain an effective concentration of released LK for supporting long-term biological processes. Cells cultured with biocompatible GLK displayed good adhesion and extensive spreading, increased VEGF product

SUBMITTER: Wang WL 

PROVIDER: S-EPMC11997346 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature