Coronin 1a-mediated F-actin disassembly controls effector function in murine neutrophils.

ABSTRACT: The double-edged role of neutrophils in effective host defense and harmful pathology is an emerging topic in clinical research. Neutrophils release highly potent antimicrobial granule compounds and reactive oxygen species (ROS) that can also be detrimental to the host and promote inflammatory diseases and cancer. Here we show that disassembly of F-actin greatly facilitates ROS production and degranulation in neutrophils. Utilizing neutrophils from Coronin 1a (Coro1a)-deficient mice, our data reveal that the actin-regulatory protein Coro1a controls this spatial F-actin deconstruction and concomitantly forms a signaling complex with Rac-GTPases, thereby promoting activation and translocation of Rac to the membrane during neutrophil activation. This functional activity of Coro1a was critical

SUBMITTER: Shaverskyi A 

PROVIDER: S-EPMC11997354 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature