Adipose cellularity as a measurement of long-term changes in body weight: a Swedish cohort study spanning 1988-2016.

ABSTRACT:

Background

Adipocyte size and number (cellularity) determine the adipose mass and may relate to long-term body weight changes.

Methods

We investigated 1014 healthy participants at Karolinska Institutet in Sweden 1988-2016 for body weight and size/number of subcutaneous adipocytes, and 273 for visceral adipocyte size. We measured body weight on 281 subjects about 16 years later. We analysed the association of baseline adipocyte size and number with body weight changes by linear regression including relevant co-factors, and the associations of cellularity (low or high number of either large or small adipocytes) regarding body weight changes by analysis of variance.

Findings

Subcutaneous adipocyte size and number and visceral adipocyte size showed strong relationships wi

SUBMITTER: Arner P 

PROVIDER: S-EPMC11997358 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature