Changes in the metabolome, lipidomein, and gut microbiota in Behcet's disease.

ABSTRACT:

Backgrounds

There is growing evidence that autoimmune illnesses are associated with the metabolome and microbiota. Because Behçet's disease (BD) is not often diagnosed as a systemic disorder, the aim of this research was to investigate changes in gut flora and metabolites in BD patients.

Methods

We used 16S rRNA gut microbiota gene sequencing and UPLC-QTOF-MS analysis to gather stool and serum samples from 12 age-matched healthy controls and 17 BD patients. The correlation between changes in gut microbiota and metabolites was then further analyzed.

Results

In contrast to healthy controls, our investigation revealed significant changes in the makeup of gut flora in BD patients. In particular, we observed that in the BD group, there was a large drop in clostridia but a

SUBMITTER: Shang C 

PROVIDER: S-EPMC11997388 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature