Bioactive multifunctional hydrogels accelerate burn wound healing via M2 macrophage-polarization, antioxidant and anti-inflammatory.

ABSTRACT: Globally, more than 300,000 fatalities occur from burns annually, and burn-wound healing continues to present significant challenges owing to the wound's propensity for infections, heavy bleeding, poor angiogenesis, and persistent inflammatory responses. The immunomodulation of macrophage polarization toward the M2 phenotype facilitates the healing of burn wounds by controlling the tissue microenvironment and expediting the transition from the inflammatory phase to proliferation. Here, a polydopamine-mediated graphene oxide (GA), tannic acid (TA), and magnesium ion (Mg²⁺)-incorporated multifunctional gelatin (Gel) scaffold (GTMG) is developed to accelerate wound healing by modulating the inflammatory microenvironment of burn wounds. GA and Mg²⁺ confer the scaffold wit

SUBMITTER: Zhao E 

PROVIDER: S-EPMC11997399 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature