<i>De novo</i> donor-specific HLA antibody development after kidney transplantation is impacted by PIRCHE II score and recipient age.

ABSTRACT:

Background

Antibody-mediated rejection (ABMR) is a major cause of graft loss in kidney transplantation, often associated with de novo donor-specific antibodies (dnDSA). The detection of clinically relevant dnDSA relies on evaluating reactivity in single antigen bead (SAB) assays. Immunogenetic mismatches between donor and recipient, particularly involving human leukocyte antigens (HLA), underpin dnDSA development. Understanding this relationship could improve pre-transplant risk assessment and organ allocation.

Methods

We analyzed 1296 kidney transplant patients to study dnDSA development, its relation to age, gender, and the role of HLA-derived peptide mismatches using the Predicted Indirectly Recognizable HLA Epitopes II (PIRCHE II) score. We categorized dnDSA based

SUBMITTER: Tian Y 

PROVIDER: S-EPMC11997444 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature