Terahertz wave targeting modulates the dedocking of neurotransmitters with receptors.

ABSTRACT: Neurotransmitters are essential in regulating the functions of the nervous, cardiovascular, endocrine, and various other tissue systems. Neurodegenerative diseases such as Parkinson's disease, depression, and Alzheimer's disease involve the loss of catecholamine neurons. One of the main challenges is the accumulation of catecholamine (CA) metabolites. Reducing the metabolic aggregation toxicity of the transmitter molecules remains an open question. In this work, we proposed a novel physical method, terahertz-triggered dedocking, to unbind ligand molecules that accumulate around receptor proteins, potentially alleviating neurodegenerative diseases. We found that electromagnetic stimulation at 44.5 THz successfully dissociates the DA ligand from the binding sites at the receptor by breaking

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC11997586 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature