Regulatory SNP of TERT promoter accompanied by C228T and <i>BRAFV</i> ^600E is an exacerbating factor of papillary thyroid carcinoma.

ABSTRACT: Despite the increased incidence of thyroid cancer due to enhanced precision of ultrasound technology and extensive utilization of puncture aspiration cytology, the mortality rate remains low, raising concerns about overdiagnosis. Papillary thyroid carcinoma (PTC) is the most common type, primarily diagnosed through cell nuclei examination. Recent advancements in identifying genetic mutations and tumor classification have refined diagnostic methods. Point mutations in the telomerase reverse transcriptase promoter (TERTp), specifically -124 C >T (C228T) and -146 C >T (C250T), and the regulatory single nucleotide polymorphism -245 T >C, C allele of rs2853669 (TrSNP) are potential thyroid cancer biomarkers. The present study tested the hypothesis that the coexistence of BRAF muta

SUBMITTER: Nakazato Y 

PROVIDER: S-EPMC11997643 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature