Uncinate Fasciculus Lesion Burden and Anxiety in Multiple Sclerosis.

ABSTRACT:

Importance

Multiple sclerosis (MS) is an immune-mediated neurological disorder that affects 2.4 million people worldwide, and up to 60% experience anxiety.

Objective

To investigate whether anxiety in MS is associated with white matter lesion burden in the uncinate fasciculus (UF).

Design, setting, and participants

This was a retrospective case-control study of participants aged 18 years or older diagnosed with MS by an MS specialist and identified from the electronic medical record at a single-center academic medical specialty MS clinic in Pennsylvania. Participants received research-quality 3-Tesla magnetic resonance neuroimaging as part of MS clinical care from January 6, 2010, to February 14, 2018. After excluding participants with poor image quality, participants

SUBMITTER: Baller EB 

PROVIDER: S-EPMC11997724 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature