Four cycles of docetaxel plus cisplatin as neoadjuvant chemotherapy followed by concurrent chemoradiotherapy in stage N2-3 nasopharyngeal carcinoma: phase 3 multicentre randomised controlled trial.

ABSTRACT:

Objective

To compare the effects of four cycles of docetaxel with cisplatin as a neoadjuvant chemotherapy followed by concurrent chemoradiotherapy with concurrent chemoradiotherapy alone by assessing reductions in distant metastasis and improvements in survival in patients with stage N2-3nasopharyngeal carcinoma.

Design

Phase 3, multicentre, randomised controlled trial.

Setting

Six sites in China from 23 February 2016 to 18 February 2019.

Participants

186 participants aged ≤70 years with a diagnosis of untreated stage T1-4N2-3M0 nasopharyngeal carcinoma.

Intervention

Participants were prospectively enrolled and randomly allocated to either the neoadjuvant chemotherapy plus concurrent chemoradiotherapy group (four cycles of neoadjuvant chemotherapy (docet

SUBMITTER: Xie WH 

PROVIDER: S-EPMC11997745 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature