Edonerpic maleate enhances functional recovery from spinal cord injury with cortical reorganization in non-human primates.

ABSTRACT: While spinal cord injury (SCI) aggravates the quality of life in humans by severe paralysis, clinical intervention to promote functional recovery from SCI is limited. We recently identified a small compound, edonerpic maleate (edonerpic MA), which accelerates training-dependent motor functional recovery from brain damage in rodents (cryo-genic cortical injury) and non-human primates (internal capsule haemorrhage) by the facilitation of experience-dependent synaptic trafficking of glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. In the present study, we investigated whether edonerpic MA accelerates functional recovery after SCI in non-human primates. Six adult monkeys (Macaca fuscata) received a unilateral SCI between the C6 and C7 segment. After the SCI, upp

SUBMITTER: Uramaru K 

PROVIDER: S-EPMC11997772 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature