The risk of sodium overcorrections in severe hyponatremia and the utility of desmopressin: a large retrospective study.

ABSTRACT:

Background

The suggested narrow rate of serum sodium (sNa) correction in hyponatremia can be difficult to respect, leading to overcorrections. Our ability to anticipate the rapidity of correction according to the mechanism of hyponatremia is uncertain. While desmopressin is often used to pause a rapid rise in sNa, its dose-related effect is also not well described. We studied the rate of hyponatremia overcorrections, its prediction and the utility of desmopressin in its management.

Methods

We retrospectively reviewed all cases of severe hyponatremia (sNa <120 mmol/L) in a large university hospital that occurred over 10 years. We assessed investigations, causes and treatments. We compared all sNa separated by at least 8 h and calculated correction rates. Significant overcorre

SUBMITTER: Lamarche F 

PROVIDER: S-EPMC11997796 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature