Langerhans cells infiltration in lymph nodes of patients with systemic lupus erythematosus.

ABSTRACT:

Objective

This study aimed to characterise the clinical features and treatment regimens of patients with lupus who have lymphadenopathy (LAP), as well as to investigate the presence and potential implications of Langerhans cells (LCs) infiltration in lymph nodes.

Methods

A case-control study was conducted to identify the clinical characteristics of newly diagnosed, treatment-naïve patients with lupus who have LAP. Lymph node biopsies were performed, and LC infiltration was assessed using immunohistochemical staining for S100, CD1a and Langerin.

Results

A total of 59 patients with SLE who have LAP (SLE-LAP) were enrolled, with 81 patients with SLE without LAP serving as controls. The SLE-LAP group exhibited significantly higher frequencies of fever (64.4% vs 35.8%, p<0

SUBMITTER: Qian J 

PROVIDER: S-EPMC11997825 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature