Mediators of epilepsy risk after traumatic brain injury: A 20-year U.S. veteran cohort study.

ABSTRACT:

Objective

Traumatic brain injury (TBI) is a significant risk factor for epilepsy, but little work has explored whether risk of epilepsy after TBI may operate through intermediary mechanisms. The objective of this study was to statistically screen for potentially mediating effects among 64 comorbidities for epilepsy risk following TBI among Post-9/11 U.S. veterans.

Methods

This longitudinal matched cohort study used an established algorithm to identify veterans in Department of Defense (DoD) and Veterans Health Administration (VHA) records with a history of the primary exposure, TBI, between 2003 and 2023, who were demographically matched 1:1 with veterans without history of TBI exposure from the same cohort. In the observation time window after index date, mediation models e

SUBMITTER: Vadlamani S 

PROVIDER: S-EPMC11997920 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature