Multifunctional Heterogeneous Cobalt Catalyst for the One-Pot Synthesis of Benzimidazoles by Reductive Coupling of Dinitroarenes with Aldehydes in Water.

ABSTRACT: The endeavor of sustainable chemistry has led to significant advancements in green methodologies aimed at minimizing environmental impact while maximizing efficiency. Herein, a straightforward synthesis of benzimidazoles by reductive coupling of o-dinitroarenes with aldehydes is reported for the first time in aqueous media while using a non-noble metal catalyst. This work demonstrates that the combination of nitrogen and phosphorous ligands in the synthesis of supported heteroatom-incorporated Co nanoparticles is crucial for obtaining the desired benzimidazoles. The process achieves >99 % conversion, >99 % chemoselectivity and stability for the reduction of dinitroarenes using water as the solvent and hydrogen as the reductant under mild reaction conditions. The robustness of the catalyst

SUBMITTER: Del Rio-Rodriguez JL 

PROVIDER: S-EPMC11997933 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature