Pattern separation involves regions beyond the hippocampus in non-demented elderly individuals: A 7T object lure task fMRI study.

ABSTRACT: Investigating the mechanism of differentiating similar representations, known as pattern separation, has primarily focused on the hippocampus. The roles of cortical regions and their interaction with the hippocampus remain largely unclear. In this study, we address this topic by analyzing whole-brain, high-resolution mnemonic similarity task (MST) fMRI data collected with a 7-Tesla MR scanner. Structural and functional MRI data were acquired from 55 non-demented elderly subjects. During the encoding phase of the MST task, participants responded with "indoor" or "outdoor" to 66 everyday objects. In the recognition phase, participants were asked to make "same" / "similar" / "new" judgments about objects that were either the same as previously seen objects (targets), similar but different fro

SUBMITTER: Yang Z 

PROVIDER: S-EPMC11997958 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature