Positron Emission Tomography Imaging of <i>Acinetobacter baumannii</i> Infection: Comparison of Gallium-68 Labeled Siderophores.

ABSTRACT: Acinetobacter baumannii (AB) is an opportunistic pathogen with growing clinical relevance due to its increasing level of antimicrobial resistance in the last few decades. In the event of an AB hospital outbreak, fast detection and localization of the pathogen is crucial, to prevent its further spread. However, contemporary diagnostic tools do not always meet the requirements for rapid and accurate diagnosis. For this reason, we report here the possibility of using gallium-68 labeled siderophores, bacterial iron chelators, for positron emission tomography imaging of AB infections. In our study, we radiolabeled several siderophores and tested their in vitro uptake in AB cultures. Based on the results and the in vitro properties of studied siderophores, we selected two of them for furt

SUBMITTER: Dvorakova Bendova K 

PROVIDER: S-EPMC11997986 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature