<i>Plasmodium</i> Infection Modulates Host Inflammatory Response through circRNAs during the Intracellular Stage in Red Blood Cells.

ABSTRACT: The integration of RNA- and DNA-based assays enables the investigation of disease dynamics, specifically assessing the role of asymptomatic or subclinical infections in malaria transmission. Circular RNAs (circRNAs), a distinct category of noncoding RNAs, are implicated in numerous pathogenic mechanisms. As of now, research has yet to explore circRNAs' function in malaria infection. The findings revealed that Plasmodium infection upregulated 60 circRNAs and downregulated 71 in BALB/c mice. We selected 11 differentially expressed (DE) circRNAs according to function prediction of target miRNA-mRNA and coding protein, and these were further confirmed by validation experiments. IRESfinder, GO, and KEGG evaluations indicated that 7 DE circRNAs possess protein-coding potential and are enr

SUBMITTER: Xu W 

PROVIDER: S-EPMC11997988 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature