Dynamic-covalent hybrid hydrogels with cartilaginous immune microenvironment temporally regulating meniscus regeneration.

ABSTRACT: Meniscus is a crescent-shaped fibrocartilage tissue for providing structural congruence and absorbing mechanical forces. Currently, the development of material-guided regeneration medicine strategy has emerged as a promising alternative for meniscus treatment. However, it often presents more complex pathological conditions of immune-inflammatory responses, and thus inevitably causes a harsh microenvironment that extremely hinders fibrocartilage regeneration. Therefore, there is an urgent need to develop bioactive materials to achieve cartilaginous immunomodulatory throughout the whole regenerative periods. In this study, we develop a novel dynamic-covalent hybrid (DCH) hydrogel with cartilaginous immune microenvironment (CIME) to temporally regulate meniscus regeneration. By

SUBMITTER: Chang Z 

PROVIDER: S-EPMC11998115 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature