Exploring causal correlations between immune cells and diabetic neuropathy: a Mendelian randomization.

ABSTRACT:

Background

Circulating immune cells reportedly affect diabetic neuropathy (DN). Although associations have been previously established between numerous biomarkers and diseases, elucidating their causal relationships remains challenging. Mendelian Randomization (MR) could overcome this difficulty by applying genetic instruments to discern causal links. In this study, we conducted bidirectional two-sample MR to address this problem.

Methods

We used freely available genome-wide association study summary statistics. We obtained immune cell phenotype-related summary data from a study cohort comprising 3,757 Sardinian individuals that reported data concerning 731 immune cell phenotypes. We obtained DN-related summary data from the FinnGen database and conducted sensitivity analyse

SUBMITTER: Ji L 

PROVIDER: S-EPMC11998185 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature