PACAP38-induced migraine attacks are independent of CGRP signaling: a randomized controlled trial.

ABSTRACT:

Background

Calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) are key pathogenic drivers of migraine. While CGRP has become the target of several mechanism-based therapies, less is known about PACAP38 signaling in migraine pathogenesis. Previous studies suggest that PACAP38 can modulate CGRP release, but it might also induce migraine attacks via CGRP-independent mechanisms. Whether PACAP38 signaling is independent of and parallel to CGRP signaling has implications for future therapeutic strategies. Here, we aimed to ascertain whether PACAP-38 can mediate migraine attacks independently of CGRP signaling by assessing the ability of eptinezumab to prevent PACAP38-induced migraine attacks.

Methods

In a double-blind, placebo

SUBMITTER: Al-Karagholi MA 

PROVIDER: S-EPMC11998216 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature