Direct RNA sequencing reveals chicken post-transcriptional modifications in response to Campylobacter jejuni inoculation.

ABSTRACT:

Background

Campylobacter jejuni (C. jejuni), is a leading cause of food-borne pathogen, poses significant threats to poultry industry and public health. Post-transcriptional modifications play crucial roles in regulating the immune system and cell functions. However, the epigenetic regulation in response to C. jejuni inoculation in chicken remains elusive.

Results

The RNA transcriptional profiles and base modification alterations in the chicken cecum following C. jejuni inoculation were characterized using direct RNA sequencing and analyzed by bio-informatics and expression analysis. We identified 40,755 transcripts and 23,877 genes following C. jejuni inoculation in the chicken cecum. Of which, 10,503 novel transcripts across 8,560 genes were identified. The number of signi

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC11998244 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature