Exogenous lactate infusion (ELI) in traumatic brain injury: higher dose is better?

ABSTRACT:

Background/objective

Traumatic brain injury (TBI) is a life-threatening critical neurological injury resulting in widespread metabolic dysfunction in need of novel metabolic therapy. Exogenous lactate appears to improve brain metabolism, but the dose of lactate required remains uncertain. However, the ideal dose of lactate remains unclear. We present a comparison of low vs high dose exogenous sodium lactate infusion in a small cohort and the previous existing literature. We propose a systematic protocol to better study the question of dose-effect n in a future larger study.

Methods

We analyzed the metabolic and physiologic effects of various doses of exogenous sodium lactate infusion (ELI) in the existing published literature and our own, single center cohort of patients wit

SUBMITTER: Vespa P 

PROVIDER: S-EPMC11998250 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature