Development of a clinical-molecular prediction model for central lymph node metastasis in cN0 stage papillary thyroid microcarcinoma: a retrospective study.

ABSTRACT:

Background

Identifying occult central lymph node metastasis (CLNM) is essential for guiding prophylactic lymph node dissection (PLND) in patients with cN0 stage papillary thyroid microcarcinoma (PTMC). This study aimed to identify molecular prognostic biomarkers associated with PTMC and develop a clinical-molecular prediction model for CLNM.

Methods

Differentially expressed genes (DEGs) in PTMC were identified through bioinformatics analysis of the TCGA database. Prognostic DEGs were selected using Cox and LASSO regression analyses, and a risk-scoring model was constructed based on these genes. The prognostic value of the model was validated using Kaplan-Meier survival analysis and ROC curves. DEG expression levels were compared between patients with CLNM and those without (

SUBMITTER: Wang J 

PROVIDER: S-EPMC11998336 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature