Proteomic profiles screening identified novel exosomal protein biomarkers for diagnosis of lung cancer.

ABSTRACT:

Background

Exosomes play important role in biological functions, including both normal and disease process. Multiple cell types can secret exosomes, which act as message carriers. Increased evidences reveal that exosomes are promising diagnosis biomarkers in malignant tumors.

Methods

In this study, we enrolled 78 participants, including 20 lung adenocarcinoma (LUAD), 18 lung squamous carcinoma (LUSC), 20 lung benign diseases (LUBN) and 20 healthy controls (NL) and we performed parallel reaction-monitoring (PRM)-mass spectrometry to screening the proteomic variation by label free analysis in exosomes from all groups, which has been widely used to quantify and detect target proteins.

Results

Total 14 protein were identified as candidate biomarkers, complement components

SUBMITTER: Feng W 

PROVIDER: S-EPMC11998344 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature