Plasma Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Biomarkers of Cognitive Decline in People With Human Immunodeficiency Virus.

ABSTRACT:

Background

We examined the relationship between neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) and cognition in people with human immunodeficiency virus (HIV) at baseline and longitudinally.

Methods

Plasma and clinical data were available from virally suppressed people with HIV (PWH) aged ≥45 years in the AIDS Clinical Trials Group HAILO study. Four neuropsychological assessments standardized and averaged (NPZ-4) represented cognition. Plasma collection date marked baseline; slope summarized longitudinal NPZ-4 changes. Linear regressions examined biomarkers associations with baseline NPZ-4 and longitudinal change.

Results

The study included 503 participants with a median age of 52 (interquartile range [IQR, 48-57]) years and observation of

SUBMITTER: Mukerji SS 

PROVIDER: S-EPMC11998551 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature