Combined Sequential Antiretroviral Therapy-Induced Immune Reconstitution Bone Loss and Estrogen Deficiency Bone Loss Are Cumulative in Mice Models.

ABSTRACT:

Background

Antiretroviral therapy causes osteoporosis and bone fractures, increasing morbidity and mortality in people with HIV (PWH). Antiretroviral therapy induces immune reconstitution bone loss (IRBL), an inflammatory reaction associated with immune system reactivation. Women represent >50% of PWH, and many are now undergoing menopause, a major cause of postmenopausal osteoporosis that also increases fracture risk. However, the interactions between IRBL and postmenopausal bone loss are poorly understood and were investigated in this study.

Methods

We used a mouse model of IRBL, which was applied simultaneously or sequentially with surgical ovariectomy (Ovx) as a mouse model of postmenopausal osteoporosis. Cortical and trabecular bone in vertebrae and femurs was assessed

SUBMITTER: Dabeer S 

PROVIDER: S-EPMC11998558 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature