Population-Based Age-Period-Cohort Analysis of Declining Human Papillomavirus Prevalence.

ABSTRACT:

Background

Most countries in the world have launched human papillomavirus (HPV) vaccination programs, and declining HPV prevalences are reported. We aimed to disentangle the influences of calendar time, birth cohort, and age by analyzing HPV prevalences in the population-based cervical screening program using age-period-cohort modeling.

Methods

All 813 882 primary HPV-based cervical screening tests from women aged 23-64 years between 2014 and 2023 in the capital region of Sweden were identified in the Swedish National Cervical Screening Registry. The odds ratio (OR) of HPV-16/18 infection was estimated comparing birth cohorts to the unvaccinated 1984-born using an age-period-cohort model. The impact of changing HPV prevalences on the number needed to screen (NNS) to detect a

SUBMITTER: Gray P 

PROVIDER: S-EPMC11998575 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature