R-spondins secreted by human pancreas-derived mesenchymal stromal cells support pancreatic organoid proliferation.

ABSTRACT: Mesenchymal stromal cells (MSC) play a critical role in the stem cell niche, a specialized microenvironment where stem cells reside and interact with surrounding cells and extracellular matrix components. Within the niche, MSC offer structural support, modulate inflammatory response, promote angiogenesis and release specific signaling molecules that influence stem cell behavior, including self-renewal, proliferation and differentiation. In epithelial tissues such as the intestine, stomach and liver, MSC act as an important source of cytokines and growth factors, but not much is known about their role in the pancreas. Our group has established a standardized technology for the generation of pancreatic organoids. Herein, we investigated the role of pancreatic mesenchymal stromal cells in the

SUBMITTER: Cherubini A 

PROVIDER: S-EPMC11998602 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature