Impulse Control Disorders and Effort-Based Decision-Making in Parkinson's Disease Patients with Subthalamic Nucleus Deep Brain Stimulation.

ABSTRACT:

Background

Impulse control disorders (ICD) are common side effects of dopaminergic treatment in Parkinson's disease (PD). Whereas some studies show a reduction in ICD after subthalamic nucleus deep brain stimulation (STN-DBS), others report worsening of ICD or impulsivity.

Objective

The aim was to study ICD in the context of STN-DBS using an objective measure of decision-making.

Methods

Ten PD patients performed an effort-based decision-making task alongside neuropsychiatric and cognitive evaluation before and 4 months after STN-DBS. Further, 33 PD patients underwent the same experimental procedures just once after an average 40 months of chronic STN-DBS. Participants were examined preoperatively in the medication on state and postoperatively in the medication on/stim

SUBMITTER: Amstutz D 

PROVIDER: S-EPMC11998690 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature