Pharmacological Treatment of Neuropsychiatric Symptoms in Huntington's Disease: A Systematic Review.

ABSTRACT:

Background

Studies focusing on the treatment of neuropsychiatric symptoms (NPS) in Huntington's disease (HD) are scarce and show a wide variation in design, outcome measures and methodological quality. The effectiveness of pharmacological treatment of NPS in HD has not been systematically reviewed so far.

Objective

To provide an overview of the available literature on the effectiveness of pharmacological treatment of NPS in HD.

Methods

PubMed and the Cochrane library were systematically searched for studies assessing the effects of pharmacotherapy of NPS, both as a primary and as secondary outcome. A risk of bias assessment was performed for each article.

Results

Fifteen articles qualified for critical evaluation: 10 randomized controlled trials (RCTs) (five pl

SUBMITTER: Andriessen RL 

PROVIDER: S-EPMC11998698 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature