Striatal Dopaminergic Function and Motor Slowing in Essential Tremor Plus.

ABSTRACT:

Background

While previous imaging studies have generally shown normal striatal dopamine transporter (DAT) binding in essential tremor (ET), emerging evidence suggests a partial dopaminergic mechanism in this condition and an epidemiological link between ET and Parkinson's disease (PD). This link seems particularly meaningful in ET patients with additional neurological signs, such as slowness of movements, rigidity, or rest tremor (ET+).

Objectives

To investigate the potential dopaminergic pathophysiology of ET+ and to compare it to PD.

Methods

Fourty-three ET+ patients, 115 PD patients and 40 healthy controls were studied using [¹²³I]FP-CIT SPECT imaging and clinical examinations. A median follow-up of 3.0 years was carried out to confirm the diagnoses. ET+

SUBMITTER: Kuusela AM 

PROVIDER: S-EPMC11998700 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature