Current Limitations of Electronic Health Record Systems in Supporting Pragmatic Clinical Trials: Insights from the eMERGE Consortium.

ABSTRACT: Pragmatic clinical trials (PCTs) evaluate interventions in real-world settings, often using electronic health records (EHRs) for efficient data collection. We report on the challenges in performing EHR analysis of healthcare provider orders in a PCT within the eMERGE consortium, which investigates the impact of reporting genome-informed risk assessments (GIRA) to over 25,000 patients across 10 academic medical centers. Clinical informaticians conducted a landscape analysis to identify approaches for evaluating the outcomes of GIRA reporting through the EHR. Of 98 identified outcomes, 54 (55.1%) were determined to be difficult to extract because they involved provider orders, which are typically documented in free text or proprietary formats within the EHR and only mapped to standardized co

SUBMITTER: Wagholikar KB 

PROVIDER: S-EPMC11998813 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature