Associations Between Plasma Omega-3, Fish Oil Use and Risk of AF in the UK Biobank.

ABSTRACT:

Objective

To determine the relationship between plasma omega-3 levels and incident atrial fibrillation (AF), and the association between fish oil supplement (FOS) use and risk for AF.

Methods and analysis

Recent studies in UK Biobank concluded that FOS use was associated with increased risk of incident AF. Conversely, a meta-analysis found inverse relationships between blood levels of omega-3 and AF risk. We performed a prospective observational study linking plasma omega-3 levels and reported FOS use with AF risk in UK Biobank. Among UK Biobank participants without prevalent AF, 261 108 had plasma omega-3 levels and 466 169 reported FOS use. The primary outcome was incident AF during follow-up (median 12.7 years). Multivariable-adjusted hazard ratios (HR, 95% confidence int

SUBMITTER: O'Keefe E 

PROVIDER: S-EPMC11998814 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature