Translational Evidence for Dopaminergic Rewiring of the Basal Ganglia in Persons with Schizophrenia.

ABSTRACT:

Importance

In prior work, a transgenic mouse model of the striatal dopamine dysfunction observed in persons with schizophrenia (PSZ) exhibited dopamine-related neuroplasticity in the basal ganglia. This phenotype has never been demonstrated in human PSZ.

Objective

To identify a specific dopamine-related alteration of basal ganglia connectivity via task-based and resting-state functional magnetic resonance imaging (fMRI), neuromelanin-sensitive MRI (NM-MRI), and positron emission tomography (PET), in unmedicated PSZ.

Design

This case-control study of unmedicated PSZ and healthy controls (HC) occurred between November 2014 and June 2018, with analyses performed between April 2023 and February 2025.

Setting

fMRI and NM-MRI were collected at New York State Psychiat

SUBMITTER: Tubiolo PN 

PROVIDER: S-EPMC11998822 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature